A four-vehicle crash on the southbound lanes of Highway 14 near Soledad Canyon Road brought traffic on that route to a standstill Saturday afternoon.
The California Highway Patrol closed all lanes at 3:42 p.m., according to Officer Elizabeth Kravig.
The Los Angeles County Fire Department responded with several units, said Supervising Dispatcher Ed Pickett.
He said the Fire Department was dispatched at 3:24 p.m,. and the crash possibly resulted in someone being ejected from a car, according to preliminary information.
Two people in critical condition were transported to a trauma center at 4 p.m., according to Pickett.
